Considering the fact that Pokemon is still a very popular and huge money making franchise, I would say no. Even if people get sick of it and lose interest, new Pokemon fans are born everyday. Obviously, the game franchise itself has to do with it, because honestly, if Pokemon was just an anime series by itself from the start, I doubt the franchise would have lasted this long. It's not just a franchise, it's a Nintendo franchise. Has Nintendo ever stopped making Mario games after so many years? No, so I think there's a snow ball's chance in Hell that Nintendo will stop making Pokemon games. And of course, if Nintendo keeps making Pokemon games, the anime will naturally continue.