Several things to answer this.
1> Not by default. Like MS Exchange's OWA needing to be enabled, so does POP3 access for iNotes by Domino Administrator.
2> If your company was like the last one I worked for, and has RSA Security for iNotes via KeyFob (Hard Token) then iNotes will NOT work, because its only supported via the IEv6/7 (maybe v8 Beta not sure). I tried using my E71-2's browser and the page would not correctly render let along allow me to login.
3> If # 1+2 is enabled above, then you'll need to wait a few more days for Nokia & IBM to launch Lotus Traveler for S60. I posted about this on my humble blog.