The E has minimal lighting, just a headlight and LED taillight, and a minimalist enduro odometer, while the S has full road equipment, full-sized headlight with high and low beam, full-sized tail light and brake light, horn, turn signals, full instrumentation and mirrors. It also has a fan, which the E does not.
S uses vacuum-slide carbs where the E has a pumper carb, but there is probably not much weight difference there.
The E used to have better suspension, but that difference has been eliminated in later models.