Seeing as that Matt and Trey have done something big or controversial for the last few years for a season premiere ("Good Times with Weapons", "The Return of Chef", "With Apologies to Jesse Jackson"), I'm expecting it to probably be on the strike. They can't avoid it, but they also might play the Britney Spears card. Either way, the strike is the most controversial way to go and will guarantee both ratings and an explanation article on CNN on why South Park is able to comment on the strike ("they're non-union, people! Now leave us alone!")...