For what it's worth, this paper may be of some interest to you. If little or nothing can be done about the rising genetic disorders in humans, it's anticipated by some that we will become extinct within this century. Perhaps mandatory genetic testing for procreation or transhumanism will become more acceptable and the status quo as time goes on. We already have seen a push towards transhumanism lately.
"Mendelian inheritance in man is “ an encyclopedia of human genes and the disorders and other traits with which they are associated. It has been in creation and updating for over 35 years and has been computerized for most of that time. In addition to the print edition (Figure 1), it has been distributed online (OMIM) since 1987 and by compact disc (MIM-CDTM) since late 1993.” (McKusick, 1998, Vol. 1, xiii - xviii)
Apparently, this database in the National Center for Biotechnology Information at Johns Hopkins University is the best in the world for the current catalog of human genes and genetic disorders.
McKusick: Mendelian Inheritance in Man,
Reported Genetic Disorders 1966 to 1999. The number
of medically reported genetic disorders in 1966 was
1,487. The number reported by 1999 was 11,099. A
curve of best fit has an R2 of 0.995.
By 2031, it is estimated (R2 = 0.995) there will be 100,000 human genetic disorders and by 2096 1,000,000 (see Figure 3). “At least one clinical disorder has been related to 1,318 of the mapped loci (roughly 30%)” (McKusick, 1998, Vol. 1, xiii - xviii). That suggests genetic disorder saturation of each locus by 2031 and supersaturation by 2096.
These data confirm human devolution and suggest imminent permanent genetic extinction in this century"
http://www.lifescienceprize.org/data3.html