sorry I can't help you much, I never had headaches from spiro but I've been on meRAB to prevent migranes since long before I even started spiro so maybe that has been a factor. Her headaches do not sound like migranes. Maybe she should stick with 100mgs. Did 100mgs help at all? Is she on a birth control pill? I've heard women complain of headaches from birth control pill maybe thats effecting her. Another factor is dehydration, Spriro is a duretic and she neeRAB to make sure she drinks alot of water, plain water or gatorade Not soda,sugary juice etc. to make up for the fluid she's losing. I hope she feels better.