3 way will sound the best. If you haven't already gotten your sub, I'd recommend a TC Sounds (AudioPulse) LMS with a Sundown amp. You'll come out with something like this: http://www.youtube.com/watch?v=DUL3dFx3U_A
Keep your midrange simple. It's only for fill in. You will already have lows, and highs. I would simply go with something relatively inexpensive for the midrange.