Here is the prime example of why you will never see a cure for cancer.

  • Thread starter Thread starter Thoth
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secondly, if this is compound is indeed efficacious in humans, pharma and academia would greatly benefit from characterizing its mechanism of action.
 
Everyone that's more educated than him that disagrees with his ill informed opinions are trolls.
 
Lets make this really simple for tin foil hat crew.

Cancer is one of the largest killers in this country today. Millions have it and thousands die from it every year.

A cure would sell like meth in Missouri but those evil pharma companies would rather push 30 year old chemo treatments that they don't even hold the patents on because the real money is in treatment, not a cure.
 
hi, magnetic fields do not treat cancer. When something is called an alternative therapy if is code word for it doesn't fucking work otherwise it would not be an alternative therapy.
 
Jesus christ, you sound like such a fucking cunt. You're probably a real "hoot" IRL. Snot nosed, elitist motherfucker who thinks hes better than everyone else.

Go slit your own wrists. You know how, since you're a doctor and all.

Faggot.
 
Big Pharma, Big Oil, Big Tobacco... it's all the same. When you fail to acknowlege the company and stereotype them all, it's hard to digest the information given as truth.

There will never be "a" (as in, one) cure for cancer. That would be like saying "Big Pharma is hiding their cure for aging." There are so many different cancers, and so many different effects of aging.

That said, it would not surprise me in the least, though, to find a pharma company hiding a cure for an illness (even a cancer) if they have something that treats it at a substaintial profit. If such things are really going on, there should be some whistleblowers, or someone that leaks the info to get their 5 minutes of fame (before Big Pharma has them killed! )
One of the reasons car makers are reluctant to make electric cars is that they are so much more mechanically simple. The service departments would go out of business not being able to sell and install engine oil, oil filters, air filters, PCV valves, diagnose vacuum leaks and "check engine light" emmissions issues, etc etc ad nauseum.
 
Therapeutic use

Owing to the highly corrosive action of the acid, only the salts of dichloroacetic acid are used therapeutically, including its sodium and potassium salts, sodium dichloroacetate and potassium dichloroacetate.
[edit] Lactic acidosis

The dichloroacetate ion stimulates the activity of the enzyme pyruvate dehydrogenase by inhibiting the enzyme pyruvate dehydrogenase kinase.[7] Thus, it decreases lactate production by shifting the metabolism of pyruvate from glycolysis towards oxidation in the mitochondria. This property has led to trials of DCA for the treatment of lactic acidosis in humans.[8][9][10][11]

A randomized controlled trial in children with congenital lactic acidosis found that while DCA was well tolerated, it was ineffective in improving clinical outcomes.[9] A separate trial of DCA in children with MELAS (a syndrome of inadequate mitochondrial function, leading to lactic acidosis) was halted early, as all 15 of the children receiving DCA experienced significant nerve toxicity without any evidence of benefit from the medication.[10] A randomized controlled trial of DCA in adults with lactic acidosis found that while DCA lowered blood lactate levels, it had no clinical benefit and did not improve hemodynamics or survival.[11]

Thus, while early case reports and pre-clinical data suggested that DCA might be effective for lactic acidosis, subsequent controlled trials have found no clinical benefit of DCA in this setting. In addition, clinical trial subjects were incapable of continuing on DCA as a study medication owing to progressive toxicities.
[edit] Potential cancer applications

Cancer cells generally use glycolysis rather than respiration (oxidative phosphorylation) for energy (the Warburg effect), as a result of hypoxia that exists in tumors and damaged mitochondria.[12] Usually dangerously damaged cells kill themselves via apoptosis, a mechanism of self-destruction that involves mitochondria, but this mechanism fails in cancer cells.

A study published in January 2007 by researchers at the University of Alberta,[13] testing DCA on in vitro cancer cell lines and a rat model, found that DCA restored mitochondrial function, thus restoring apoptosis, killing cancer cells in vitro, and shrinking the tumors in the rats.[14]

These results received extensive media attention, beginning with an article in New Scientist titled "Cheap,
 
shit man, you've convinced me. If only we had some way to prevent horrific, disfiguring diseases. Disease like polio.

oh wait...
 
I think they will just end up making a hybrid that is marketable.

I doubt the trolls will even look at this one...but those interested should have a look.

http://www.ncbi.nlm.nih.gov/pubmed/20007777

http://www.thedcasite.com/Library/Lippard_Mitaplatin,_a_potent_fusion_of_cisplatin_and_the_orphan_drug_dichloroacetate.pdf
 
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