Narrator: The dream was over. Coming up, was the dream really over? Yes it was. Or was it?
Wiggum: Wait a minute--Bronchial tubes clearing...asthma disappearing! Acne...remains, but...asthma disappearing!
^Again, the way Hank delivered it makes it hilarious.
Homer: Ah, 8:58, first time I've ever been early for work. 'Cept for all those daylight savings days. Lousy farmers.
Farmer: Oh, no! The corn! Paul Newman's gonna have my legs broke.
Bart: I wash myself with a rag on a stick.
Thief: Hello.
Homer: All right, pal: where'd you get the sugar for that tea?
Thief: I nicked it when you let your guard down for that split second, and I'd do it again. Goodbye.
And to cap off this post...
Homer: Never, Marge! Never. I can't live the button-down life like you. I want it all: the terrifying lows, the dizzying highs, the creamy middles. Sure, I might offend a few of the bluenoses with my cocky stride and musky odors -- oh, I'll never be the darling of the so-called "City Fathers" who cluck their tongues, stroke their bearRAB, and talk about "What's to be done with this Homer Simpson?"
EDIT: Forgot this classic...
Homer: Ooh, look at me! I'm making people happy! I'm the Magical Man from Happy-Land, in a gumdrop house onLollipop Lane! Oh, by the way, I was being sarcastic.
Marge: Well, duh.