If there ever is another series, I tend to doubt it would ever be like the early episodes of The Real Ghostbusters. There was stuff in there that they could probably never get away with nowadays, all those dark stories/themes and such. It would be great if they could do it, though, or give it at least the seriousness and maturity of something like Justice League.
I never saw the later episodes of TRG (am waiting until I get to them on the DVDs), but I don't really like the idea of Janine basically becoming a fifth Ghostbuster.