Not really much of a heart-throb but Phillip Seymour Hoffman's acting is very much like the Depp model of portraying quirky characters. Check him out in Capote and you'll see what I mean.
Also, not male but female, Cate Blanchett is to me one of the most powerul actors around at the moment. She is able to carry off any accent, any character with ease.
Benicio Del Toro is also great but has been way too quiet recently.
A clutch of others: Javier Bardem, Paddy Considine, Michael Sheen and Sally Hawkins.