I doubt it. Game manufacturers for the Gamecube, Dreamcast, and PS1 have had multi-disc games. I'm not aware of any on the xbox or ps2, but if they wanted to make some epic games, they could easily just make it and put it on multiple discs. It'll probably be a while before any game manufacturer makes a game that takes up 50GB. It'll probably be right around the time that these 3 consoles are at the end of their lifespans.