One I found somewhat annoying was Wart exclaiming 'WHOA-WHUT? WHOA!!' constantly during Disney's Sword in the Stone. It was a particulary jarring case since the voice acting for that character was pretty much all over the place during that film.
During regular animation though, I think there are cases where it's merely used for comedic effect. 'Ed, Edd n' Eddy' and 'Courage the Cowardly Dog' were particulary good at pulling it off without it becoming obnoxious.
"Fine! You can stay in there forever!" "...But it smells funny."
*4 episodes later*
"Actually Eddy, it's hip! it's now!.....but it smells funny."
And who doesn't crack up every time they hear that same 'gravy'' and 'where's my dinner'?