Run your mule 24/7. Thats the classic way of using emule efficiently.
As stated above, if you want speed, use bittorrent, if you want the rare stuff, use emule.
although, if you first started on bittorrent and are just now discovering emule, you'll find it hard to adjust to the speeds and the whole principle. luckily, i started the other way around and have the patience to make the best of it.
i dont use no upload
i just use removed ratio
But after a while speeds went up to 50kbs and sometimes its been up to 100kbs, which is what I get for torrents. Patience is key!