Pacino shades De Niro for me, those 2 are in a league of their own, the fact it took so long for Pacino to win the Best Actor Oscar is more down to the Academy voting than Pacino's talent.
Coming in behind them I'd have Eastwood, Jean Reno and Freeman
Actress is a bit harder, I don't know if its down to a lack of powerful roles being written for women but I think the Actress scene isn't great right about now.