the most significant and why? 1) US Atom Bomb Test New Mexico,.. 2) Kennedy's Assasination,..3) The 1st Moon Landing,...4) 9-11 Twin Towers Attack,..5) Barak Obama become US President
It has to be the twin towers attack, because from then on we have lost our sense of being safe here in America and it has added a nightmare to traveling now.
3 probably #1 and 2 probably number two, but it's going to depend on your generation, since different moments have importance to different generations (they were different ages when it happened). i'm 48.