I was taking 1 prilosec a day and it didn't last long enough. After 20 hours, I had heartburn. Now I take 1 in the morning and 1 at night and they overlap so i don'y have heartburn anymore.
Nexium didn't work for me and I was taking it twice a day.. doctor switched me to Zegerid 2xs a day and that seems to work as long as I don't start eating things that trigger Gerd...