Yes, but better under dark skies, with clear, calm air overhead. You can see most with a 4.25, and all with a 6, and brighter with an 8 inch fast newtonian.
Also quite a few NGC galaxies and clusters, some planetary nebs at high power, Moon and planets of course, perhaps some dark nebs too if very clear.
Many on line sources of lists of objects brighter than 11th magnitude for extended objects, 13th magnitude for stars.