What kind of engine to put in my 88'' Toyota Pickup?

This truck is used as a mudder and for transportation, to work and to school. She has a 22RE with 252, XXX miles on her. She's a 5 speed and 4x4, and has a 3" body lift. I would just leave the 22RE in if i didn't wanna put 35" boggers on her, along with a 6" suspension lift plus, its about time to put a new engine in the truck.. I want an engine that is going to give me enough power and fuel efficient. Im wanting to put at least a 4.0 L in her. Anybody Have any suggestion or advice?
I was considering the 350 4 bolt main, but wont i have to put a new tranny in? And I assume i'm going to have to move the motor mounts as well as add some?
 
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