Well, I can tell you about karate.
Karate includes strikes to weak points.
Karate includes techniques that exploit joints, small digits, etc
However, karate relies on a lot of strikes, so you will have to do some strength building exercises. Any striking art would need strength. You can't always hope to get someone in the face, throat, eyes, temple, floating ribs, etc. You need some strength around the punch, especially around another strike-style martial artist who is more likely to defend these areas.