What is meant by the statement “RNA polymerization is thermodynamically

M

Matt

New member
What it is referring to is energy. All processes in the cell must have some basis by which they are driven to completion, and it is saying that for RNA polymerization, the mechanism that powers this is hydrolysis of an energy molecule.

For this case, more specifically, it is referring to the fact that all ribonucleotides occur as triphosphates. Think of the ribonucleotide as a molecule of ATP if this helps. To drive the polymerization reaction forward, the cell uses the energy of the triphosphate bound to the nucleotide as it would ATP for other cellular processes, the hydrolysis of which releases free energy to create the phopshodiester bonds between two or more nucleotides.

So, put simply, by breaking off the two phosphates (i.e. - hydrolysis of this bond), it is able to release energy that can be used to make a bond, say, between these two nucleotides.

I hope that helps. =]
 
What it is referring to is energy. All processes in the cell must have some basis by which they are driven to completion, and it is saying that for RNA polymerization, the mechanism that powers this is hydrolysis of an energy molecule.

For this case, more specifically, it is referring to the fact that all ribonucleotides occur as triphosphates. Think of the ribonucleotide as a molecule of ATP if this helps. To drive the polymerization reaction forward, the cell uses the energy of the triphosphate bound to the nucleotide as it would ATP for other cellular processes, the hydrolysis of which releases free energy to create the phopshodiester bonds between two or more nucleotides.

So, put simply, by breaking off the two phosphates (i.e. - hydrolysis of this bond), it is able to release energy that can be used to make a bond, say, between these two nucleotides.

I hope that helps. =]
 
What it is referring to is energy. All processes in the cell must have some basis by which they are driven to completion, and it is saying that for RNA polymerization, the mechanism that powers this is hydrolysis of an energy molecule.

For this case, more specifically, it is referring to the fact that all ribonucleotides occur as triphosphates. Think of the ribonucleotide as a molecule of ATP if this helps. To drive the polymerization reaction forward, the cell uses the energy of the triphosphate bound to the nucleotide as it would ATP for other cellular processes, the hydrolysis of which releases free energy to create the phopshodiester bonds between two or more nucleotides.

So, put simply, by breaking off the two phosphates (i.e. - hydrolysis of this bond), it is able to release energy that can be used to make a bond, say, between these two nucleotides.

I hope that helps. =]
 
assisted by PPi hydrolysis”? What is meant by the statement “RNA polymerization is thermodynamically assisted by PPi hydrolysis”?

I would be so appreciative if someone could explain this to me a little. I'm not sure what it means. Or give me a good website description? I tried looking it up, but with no luck. Thanks!
Thank you so much, Matt! And for my last question. :) You are better than my professor at helping me understand.
 
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