Well we need to know what model Honda and if you are building this frame for a chopper or are buying one and if so which one.
As for the idea, the Honda needs a charging system which most of those components on the stock bike are up under the seat. Other than that the engine should be able to be adapted into a chopper frame. They use to do it with the old inline 4's the CB 550,650 and 750 were all used as chopper motors.