Stream of thought:
Opening the season with a LIsa / travel episode... yipes. That said, the jab at This American Life was perfect, and the pacifier as cigar was classic.
It's bad when the first musical number hits, and the first thing I think is "Ladies and Gentlemen, Conway Twitty" in as much as the segue into this musical number is about as abrupt.
Hey, it's some Flight of the Concords, which I guess is a little more with it than option 2 (Jack Black,) but still just as awkwardly referential.
Really, Krusty at the Hague? The Nobel Peace prize wasn't absurd enough. I guess it's a jab at the whole Roman Polanski ruckus, but the joke/satire is so muted and buried that the humor is lost.
Another little song, and while I like Flight of the Concords, you pretty much have to to enjoy the song. As not everyone has seen or even heard of the show, I have to wonder who they are going for here by having them guest so prominently.
The MC Hawking bit is cute, though 10 years late. I guess consequentially though, I can expect MC Frontalot and/or MC Chris to turn up in a Simpsons episode around 2012-2017.
The wonderful reference to the opening sequence was schmaltzy, but executed so perfectly that I'm shocked we hadn't seen a trick like this in the series sooner.
"You will never be able to walk up stairs like an 8-year-old girl" - Sad Grandpa.
A Simpson running away? Has any member of that family not just booked it at some point?
The Brontasaurus sisters... sounds about right?
The horrible joke about NYC neighborhoods. Meh. However, it is true that in any city, the hipsters (almost of whom grew up in small towns as social outcasts,) inevitability pick the cheapest, skidsiest part of town, and eventually gentrify it. It's not funny because you can pick almost any big city in the US or Canada and find a neighborhood where this very thing is happening.
The artist song is a reminder of why I'm in school for computer science, and not music, even though I have as much talent for the latter as the prior.
WE'RE REGION 1! Classic, and funny.
Hilter: always worth having a joke at his expense.
Oh boy, I've seen that coffee house. I've been tempted to play that coffee house.
Ah, another happy Lisa ending. However, it's been done before and better. Can't say I didn't "daw" at it though.
Final Thought: Ultimately, it's not as powerful as the Bleeding Gums episodes, and it feels more like a Simpsons/Flight crossover than a Simpsons episode. Pretty weak in that sense.