Are we talking about the old show from the early seventies, with Roger Moore as the English Lord and Tony Curtis as the American Playboy? Gosh I used to love that show! But I can't remember much about it now.
My first instinct is to agree that this won't work, though, despite the success of Starsky and Hutch last year. While Starsky and Hutch was probably bigger than The Persuaders, all told, neither Paul Michael Glasier or David Soul were cream of the crop actors. In contrast, I don't think that Steve Coogan and Ben Stiller are big enough to fill the shoes of Moore and Curtis.