I think we're going to see less and less cutaways as the show gets it's footing, like American Dad did. This show will hopefully get out of Family Guy's shadow by mid season.
22 for S1, 22 for S2, and possibly 22 for the additional season Fox just ordreed. But more than likely, they'll start holding episodes back like they do with the other animated shows, so when is all said and done there's going to be enough eps to take it through season 4.