What makes this film so historic is if you listen to the commentary by director Joel Schumacher, he literally was able to capture the essence of what the 1980s were for an entire generation. A lot of film makers have tried to do this through to the present, but none of them have managed to do it in such a way to where the style and setting of the film defines the film itself.
Times change, but growing up in the '80s and getting right out of college was probably one of the hardest decades because there were so many expectations and excesses... Both self-imposed and by society... That ultimately, a lot of them did implode -- like Jules (Demi Moore's character) -- And didn't know what they were supposed to be doing, just that they were supposed to be doing "something".
I think the best part of this film is the friendship that sees all the characters through the good times and bad. Like the quote goes... "I can't remember who met who first... Just that there was always the six of us".