Hi, DepenRAB on the severity of acne I think. For me, 6 - 9 months before I really could say my skin was completly clear. I take 150mg daily, anything less just didn't work for me. Some people get results with much less, but my dr. started me slow, 25mg at a time to make sure I could take it w/o complications. I tried to lower my dose recently, and broke out. So find the dose that works for you and stick with it. It takes time, be patient. Beautiful skin will happen -