Safe to run computer with the case off?

Yea, but if you do it for extended periods of time dust will find it's way into your pc and cause some problems later on.
 
You can do it, but it will probably pick up more dust, everything will be exposed, and your gonna need a way to turn it on.

It's fine if your testing a new build, or just to do a temporary thing but I wouldn't run it case-less 24/7.
 
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