Things are going allright-- for those of you who don't know...I started taking 25 mg a day on Nov. 21, and gradually worked up to 200mg a day on Dec. 12. My side effects have mostly gone away. Before, I would feel really jittery and lethargic, but now I'm fine. I have been drinking A TON of water, and making sure I eat a lot throughout the day. Unfortunately, my skin is very very dry, even when I glob on moisturizer. I tried using Aveeno's daily scrub for awhile to try and get rid of the flakiness, but that made things worse, so I stopped. I decided about a week ago to stop taking Minocycline (which I had been taking for years). I'm hoping Spiro alone will do the trick, although all the times in the past that I tried to discontinue Minocycline ended in me breaking out and then starting to take it again- hopefully this time will be different (*knock on wood*)! As far as my acne goes, I've had a few zits here and there, but nothing huge. Pretty much about the same level of acne that I had before taking Spiro. I'm also taking Spiro for mild hirsutism, and that seems about the same so far as well.