Only Children in Animation

If we're counting animated movies as well, we can include Hogarth Hughes from The Iron Giant (1999) and Coraline from the movie of the same name.
 
As far as I'm concerned, Pan is an only child as far as Dragon Ball GT is concerned. Gohan and Videl didn't have another child after Pan as far the ending to GT is concerned.
 
In the story of Narutaru, almost every major kid is an only child.
Shiina was thought to be one, until the Otohime reveal near the end

In Bokurano, every kid (except for Jun) is an only child.
 
One interesting case is Iceman. In most of the animated adaptions he's portrayed as an only child, but in Spider-Man & His Amazing Friends he had a half-sister and in X2 he had a little brother.

Kitty Pryde's also an only child, I believe.

Sonic the Hedgehog, Tails, and pretty much everyone in the Sat AM series were only children as far as I know (unless new silbings popped up in the comic that I'm not aware of)

Kit Cloudkicker (Talespin) can be assumed to be an only child, being orphaned and all.

The Mystery Inc gang (Minus Shaggy & Scooby) were all only children. I don't recall ever seeing siblings for Fred, Daphne, Velma, Scrappy, or Flim Flam.
 
I got a few more, this time from Pokemon.

Ash Ketchum- Obviously an only child. We only seen his mother. His father's presence is still up in the air.

Dawn- Same as Ash, we only saw her mother as well. Most likely only child as she doesn't mention any siblings or what it is like to live with them, compared to Misty and May, who obviously have siblings.

Tracy- Could be only child, however, we haven't met any of his folks.
 
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