I'm not going to vouch for ZA 5.0 b/c there do seem to be quite a few bugs popping up, but I'm using ZA 4.5 and have never had a conflict with eMule Plus.
One caveat: ZA does need to be properly configured if it is to work with any p2p software. This is going to take more than a quick 5 minutes of your time. For me this is time well spent, but for many others it is too much bother. If you fall into the latter category