Can't say i'm really into the prequel thing either (look what happened to Star Wars!) and i think the Kirk/Spock thing has had its day and any further stories would most probably just mess up the timeline.
Personally, i think a new film with a new crew on a starship in the alpha quadrant set in the next gen/RAB9/voyager timeline would be the way to go as that was always what worked best. They could use the film as some kind of major expensive pilot episode (with some kind of ending) that if it worked, and took mega box office, the actors would have it written in their contracts that they have to do at least one season of tv, also with a new class of starship with fancy new weapons and perhaps turmoil in the universe and starfleet on the brink of collapse due to conspiracys and that kind of thing (bit like firefly i guess!).
If the writers went down that route then you could always have guest appearances from the 3 series i mentioned which would always keep fans happy. I think if they had some kind of back story (revealed later in the series) about how the Borg were defeated and have been stuck in the Delta quadrant somehow with no warp capability so there would be room for a new alien race hell-bent on not assimilating but just totally destroying all remaining life in the universe and you could have every major race unwillingly but having to join forces to defeat them, it could be epic.
Oh, and maybe bring in a new Q!