Stan managed to outwit Francine a couple of times in "American Dad"
One where Francine pretended to kidnap Roger in an effort to show that Stan cares about him, which backfired because Francine called from her cell phone and Stan has caller ID.
Another had Francine trying to have Stan open up to her, and he does, which gets to the point where Stan tells her that he killed her friend's husband. This turned out to be a cover story he and Roger made up to get her to stop annoying him.