Lyrica is not an opiod, its actually an anti-convulsant drug used to treat some seizures and nerve disorders. I think it was also recently approved to treat Fibromyalgia. I am currently taking Lyrica and Soma (muscle relaxer) but there are no adverse reactions if taking both, though I do not take them at the same time. The Lyrica can make you feel really strange, though, and it's a bit hard to describe. If I take Soma with food, I have no effects one day I hadnt really eaten, took Lyrica first, then 2 hrs later took Soma. OMGGG I was spinning so much I got kinda scared. After a while, that sensation wore off some and I had no other reactions. But my doc, pharmacist, and drug interaction checkers all said there were no adverse reactions if taking both. I think Soma might be stronger than Flexeril, though.