Each person is different therefore the solution will be different. A good comfortable seat is one of the the keys to Ld riding. I do a IBA ride every year. You have 24 hours to get the 1,000 miles in on a saddle sore so you really do have plenty of time. I have done them under 13 hours and then I have took my time and it took 23 hours. I was enjoying myself so much last year I almost didn't make it. Speed isn't that important, up to a point. I have my cruise pegs adjusted to use them several ways for LD riding. My seat on my ultra is a stock comfort seat that BadX did for me. It does a great job and have not yet had numbness, or burn. I always take at least 15 min. rest stop when fueling and eat a good meal at least once. I mean a good ole country style meal. I have discovered that if I use bottled water with the lemon in it I do not get thirsty. Might be me. Plan your route and make sure you keep good records of everything at every stop. 1,000 miles is much easier than you think it will be. I have a gel pad that I carry with me but when I am riding the Ultra I don't need it. But if I am on a 1,500 mile ride I ride my other "H" bike with a corbin seat I use it, pluss I can cover some miles quick. Good luck on your venture and let us know how it went. I will not be surprised if you say "it was easier than I though it would be".
jim