I am running ford 7.3 with DP-Tuner and from everything I have heard about Duramax the only way to go is PPE. Make sure you do something with intake like AFE and Exhaust ( farmboysdiesel.com has pretty good deals ) and get some gauges to watch what is going on. Do not know if you have any exp. with the diesel tuners but it is insane-your truck will be nearly twice as fast.