Up until recently, the medical establishment's consensus was that, hypothetically, you could or should be able to stay on PPI's forever or that's what I was told three years ago. If you now google "safety of long term PPI use," for example, you will find newer literature suggesting that is not so. Two new studies just came out published in a journal called the Annals of Internal Medicine or something like that. I may go back and try to find the exact source.
How long is it safe to use PPI's? I took Aciphex for three years with no apparent negative side effects. Yet, when I had a Dexa scan earlier this year, I found out I had advanced osteopenia (the precursor of osteoporosis). How I know the Aciphex caused or greatly contributed to this condition is that I had a baseline Dexa (by coincidence or providence) the same year I began to take the Aciphex and my bone density was, not only normal, but darned good back then. Everyone was baffled when I had another Dexa in January 2010 when it came out with the osteopenia. I then reminded both of my doctors that I was on Aciphex, and they both said "Ahhh, that's it!" However, neither suggested I get off the medication. Both suggested instead that I start taking another medication for the bone loss and then add even more Aciphex if the Actonel both suggested gave me stomach problems (apparently that is a common side effect of Biphosphonates).
I am not a medical doctor. I just have common sense and like to read. It really made me mad that neither physician picked up on this but both agreed once I brought it up. It also makes me mad that neither suggested I try to get off the PPI. I am not hearing of doctors discussing potential side effects of medications with their patients.
How long is it safe to use a PPI is probably an individual matter. In my case being a woman in my mid fifties, osteoporosis and potential hip fractures are areas of concern (per the literature). I now hope I don't become a statistic.
Rose