Being safe on file swarming network is an illusion. Now if you mean you don't want to be targeted by retarded MD/MS hired by RIAA/MPAA. Then to reduce the risk go update your ipfilter from BISS everytime they release a new update. Also keep fixed ED2K server or just go pure KAD, while using random ports and not using standard along with enabling protocol obfuscation.
TIPS: Don't share NEW files like movies, music, ect just use common sense and you will be fine.