There really is no one-size-fits-all answer to this, it's completely different for everyone, and you'll find out for yourself when it happens.
Because you've never had anything as big as a penis inside your vagina before, it will hurt a little as it's stretched out - so obviously this depends on whether your hymen has been torn before, how big his penis is, and how gentle he is. As well as that, it will hurt more if you're not wet enough (because there's more friction), or if you're nervous about it (because your muscles tense up).
So there are lots of things that influence it. For most girls it will hurt a bit the first time, and after that it'll be fine - but for some girls it doesn't hurt at all, and for others it hurts for the first four or five times. Sometimes it can even feel a bit uncomfortable the next day as well. But of course, once your vagina has got used to it it'll feel really good! It just takes a bit of time to adjust to, and you might even feel the pleasure of it the first time. Eventually, you may get to orgasm from it - although there are many women who can't orgasm just from sex. (If you've never had an orgasm before - yes, they are very very nice!)
Most importantly, you need to make sure you're doing this with someone you really trust and feel completely comfortable with, and he needs to know that he has to go very slowly and gently. Don't be afraid to tell him what to do, because if he has any sense he'll be just as nervous as you about hurting you! It's reported that two thirds of women regret losing their virginity the way they did, so make sure you're not doing something you might regret later. If in doubt - any inkling of a doubt at all - it's always better to wait. Better safe than sorry!
And obviously, use a condom
If you have any more questions, email me