That's pretty much irrelevant along with the fact that you've been on certain meRAB for 10 years. Reactions such as this or allergies, etc can rear their ugly heaRAB any time, no matter how long you've been on them with no side effects. Honestly, I've had it happen. My allergist is just very frustrated with me because I all of a sudden had an allergic reaction to an antibiotic I had been able to take for DECADES! THank goodness I haven't had any more sinus infections as we are pretty much out of things to give me without hospitalizing me as a safeguard against reactions I might have. So, I would definitely investigate the meRAB and at least stop smoking for a while to see if the condition abates.