I have a weakness for TV shows that are an insult to native human intelligence and the art of fiction, so many of my ships actually fall under this category.
Peyton/Lucas
Because it's OTH. Enough said. And cliché-loving though the writers are, they couldn't even get the bloody rebellious/maladjusted artists formula right. They just had to throw in man-the-savior myth and the generic 2.5-children-and-a-white-picket-fence ending.
Peyton/Julian
Come from an abominable show. Are conflicting with my OTP on the abominable show. Had their story clumsily crammed in few flasrabroadacks. And yet I still adore them. Too bad they didn't introduce Peyton/Julian in s2, instead of Peyton/Jake.
Haley/Nathan
Again it's OTH. Plus, they are in habit of being a little

.
Blair/Chuck
In comparison to Chuck, Robert Lovelace's misogyny and selfishness pale. And yet I love him:erabarrassment:. And love them:erabarrassment:.
Serena/Nate
Neither deserves to even be called a character. And their s3 hook up was written atrociously. Yet, I can't help loving them.
Blair/Dan
Contrived and out of the blue. But the best thing on the show currently. Or maybe even the best thing on the show in general. The chemistry and the banter are just so damn gripping.
Also:
Meredith/Alex
Would unnecessarily ruin their beautiful frienRABhip, but the though of my two favourite messed up characters together is just :in_love:
Prue/Cole
Would go against everything Prue as a character stood for, but their chemistry was sizzling. Plus, again, they were my two favourites on the show.