From
Treehouse of Horror V:
Homer: Hmm, cable's out. Think I'll have a beer. (checks fridge) Hmm, not a drop in the house. What do you know?
Marge: Homer, I'm impressed. You're taking this quite well.
Homer: I'LL KILL YOU! I'll kill ALL of you!
^ Timing is everything. Also, from segment 2:
Bart/Lisa: (robotically) Join us, father.
Marge: It's.... BLIIIIIIIIIIIISSSSSSSS.
^ The dragged out "bliss" gets me every time.
From
Who Shot Mr. Burns Part 1:
Mr. Burns: Well, me and my fourth form chums think it would be quite corking if you'd sign over your oil well to the local energy concern.
^ "Corking" gets me to laugh. Nobody nowadays talks like that.
From
Pokey Mom:
Skinner: You know, when Superintendent Chalmers suggested a school mural, I almost thought he said a "school MURIEL." (audience is silent) Muriel's his sister, and uh... (a shotgun is heard in the crowd)
^ It's not so much the line itself that's funny but the shotgun in the crowd. It's even funnier that it's the second time in the episode that it's happened; is it the same person, or does Springfield just have a bunch of impatient trigger fingers?
From
Trilogy of Error:
Dr. Nick: "Inflammable" means "flammable"?! What a country!
^ And speaking of Dr. Nick...
From
The Girl Who Slept Too Little:
Dr. Nick: Remember: You have a check-up next Thursday!
Lisa: We don't go to you anymore! We have a better doctor!
Dr. Nick: Oh, congratulations!
From
The Joy of Sect:
Hare Krishna guy: Have you heard of Krishna Consciousness?
Homer: This, Bart, is a crazy man.
^ I love how Homer says that line, especially right in front of the guy.
From
Treehouse of Horror XIII:
Billy the Kid: ...And the most feared German dictator of all time: Kaiser Wilhelm!
Frank James: He ain't no cowboy!
Kaiser Wilhelm: Sure I am! Uh, yippy wippy, wippy!
From
Stark Raving Dad:
Smithers: Careful, men: He wets his pants.
From
Homie the Clown:
Woman: (on intercom) George Carlin on three.
Krusty: (answers intercom) Yeah? (listens) Lawsuit? Oh, come on. My "Seven Words You Can't Say on TV" bit was
entirely different from
your "Seven Words You Can't Say on TV" bit. (listens) So I'm a thief, am I? Well, excuuuuuuuse ME! (to accountant) Give him ten grand.
Woman: (on intercom) Steve Martin on four.
Krusty: Ten grand.
^ LOL. How did Steve Martin hear him just now?
From
In Marge We Trust:
Skinner: Mother's gone too far: She's put cardboard over her half of the television. We rented "Man Without a Face", I didn't even
know he had a problem! What should I do?
Lovejoy: Well, maybe you should read your Bible.
Skinner: Um, any particular passage?
Lovejoy: Oh, it's all good.
From
Homer vs. Patty and Selma:
Bart: What a day, eh, Milhouse? The sun is out, birds are singing, bees are trying to have sex with them, as is my understanding.
From
Worst Episode Ever:
Agnes: Out of the way, tubby.
CBG: Oh, pardon me, Oldie Hawn.
Agnes: Why, you ill-mannered sack of crap!
CBG: Oh, goody. Now I know whatever happened to Baby Jane.
Agnes: You are the rudest man who ever... bought me dinner.
CBG: Correction: I do not believe I have ever bought you... Oh.
^ There's something delightfully low brow about this exchange. Two people are attracted to each other through insult comic punchlines.