I moved over from Mozilla 3.0 to full time Chrome about a week ago and so has a few of my other friends. I have been using Chrome since launch...mainly checking for cross browser compatibility when web designing. I soon feel in love.
My friends and I are all fairly knowledgeable with technology (as I am sure many of us are on these forums) and I would say the largest downside is 3rd party add-ons are not present at the moment with Google Chrome, but that will soon change.
I found Chrome to be far better and dealing with websites with a high about of JavaScript and flash. In many situations I will have multiple tabs open of videos and a websites (which of course as a few JavaScript running) and my older computer would not handle is on IE, Mozilla, or Safari (they allocate resource poorly when dealing with JS and Flash), while Opera and Chrome do a wonderful job.
There are many other great freatures, but this is the one I seem to notice more often then not. I have enjoyed Chrome and for now I am sticking with it.