Star Trek - after Bones hypos Jim, Jim wakes and runs frantically around the ship. Chris Pine and Karl Urban worked perfectly off each other. Favorite bits within the scene:
(Bones stabs Jim again) "Stop it!" Jim yelps, glaring.
"...was the ship wallulla?"
"What?"
(turning to Bones) "Whas...whas wrong with my tong?"
"Got numb-tongue?"
"Nuhtung?"
Diary of a Mad Black Woman - this entire movie is hilarious, espcially the first half hour, but my favorite part has always been when Madea goes up against the homewrecker in the other woman's closet as she's riping up Dolche and Gabanna.
"Call the po-po. Call the po-po, hoe."
Oh, and the entirity of the Hangover.