I dislike it when characters are presented as intellecual mostly or only because they know a lot about "high" culture, like classical music and such. Not that i have anyhting against classical music, it's just that it's idiotic to honestly think that listening to it and knowing a lot about it's composers somehow makes you a smarter person than those who listen to rock or pop music. Being intelligent means having a high IQ, not knowing the names of all Beethovens sympohies. Defining yourself as intelligent only because you indulge yourself in high culture means that you are what is known as a pseudo-intellectual.
And for this reason, i have kind of a distaste for Brian in Family Guy, who often falls into that "im-smarter-than-you-because-i-know-how-to-pronounce-the-name-of-some-french-wine" territory. Like how when he declared a girl he went out with an idiot on account of just that, that she pronounced the name of a wine wrong, (and also didn't know anything about Mozart). And considering Brian is something of a confirmed author avatar, i suspect that Seth himself might be a bit of the same breed...
There is of course one such psedo-intellectual (who have also proven himself to be genuenly intelligent as well, it should be noted) character that i do like, and that's Sideshow Bob; in fact, he is one of my favorite Simpson characters. And a big part of the reason why i love him so much is because he is a parody, one might even say a deconstruction, of the "cultured" gentleman, as he sees his supperiority over "average" people as being so great that he have all right to abuse them any way he wants, and, when he is feeling alturistic, to attempt to teach them his cultured ways and turn them into proper gentlemen like him whether they want to or not.
I also like Lisa, because even though she also occasionaly act's like something of a snob, she seems to not be so much obsessed with elite culture in particular as simply obsessed with culture; mainstream culture, counter-culture, and also elite culture. She seems to find anything from Bach to Itchy & Scratchy to outsider art made by mental patients interesting, an i like that about her. And of course, she is also a very likable character in many other respects as well.