Von Doom's background is not connected at all with the cosmic cloud in the comic. He's just hideously scarred after an explosion in a lab, hence the metal mask. Also, Sue Storm was not really associated with Von Doom like she was in the movie.
Really? Whilst I liked the Human Torch stuff, I thought the stretch effects were on a par with the CGI in the first Spidey film - which were a bit sub par in this day and age.
Still an ace film though.