This would be tricky.
You could use javascript to reverse the direction of all the text on the page. Most letters have a flipped version somewhere in Unicode, so you could replace every letter with its mirror image.
I don't know how to do this with images, unless you actually make an alternate flipped copy of every image (there are ways to batch that process).
You could also (my idea) turn every letter or word into a free moving object, and they all repel/attract to the mouse cursor.
