At first I wasn't going to bother to respond to this thread because I've never weened off anime completely since I have been into it BUT in the more recent years I don't try to make that my ONLY and DEFINITIVE interest. Also my interests in anime don't devolve into watching every Tom, Dick, and Moe show out there and it takes a lot more to get me into a series than it used to.
Currently I keep up with:
Digimon 02 (Watching sub of favorite series, Crunchyroll stream), FMA: Brotherhood (Remake of popular series,Funimation stream), Dragonball KAI (Remake of old series), One Piece (favorite anime and manga series period), Slayers Evolution-R (restart of classic series)
Now notice how everything I'm watching is either from my personal "classic" era (which was about 1996-1999) or during the anime boom (2000-2007).
These days I hardly set foot into Best Buy but on the manga side of things I'm still keeping up with a lot of series (Berserk, Buddha, Black Jack, FMA, anything from the Shonen Trinity, Honey & Clover, Flame of Recca, Oh My Goddess, Legend of Zelda, Pluto, 20th Century Boys, etc...) but I think that's mainly because most older manga series are still being released here and while I'm just as picky it's a lot easier to get into a new manga series and not feel daunted.
But I haven't really bothered with trying to get interested in stuff like Hayate the Corabat Butler, Ghost Hunt, Clannad, even Code Geass. It's not because I have no interest in these shows but with DVRAB in stores taking a downturn and the concept of public anime clubs and showings dying quick deaths its come down to I feel a little more removed from the fandom than I used to be.
I also almost feel like that the Japanese otaku stigma that was a social killer in Japanese society has rubbed off on Americans somewhat. It used to be that despite my interests in anime it was easier to find non-anime fans to talk to that didn't look down on me for being into it or find people who if they were into it were broad minded enough to agree with some of my viewpoints on it.
Now I encounter too many people where if I'm not watching their trashy reality TV (which really isn't good TV and stopped being "real" quite some time ago) or their super serious crime shows I must be a grown manchild for being into anime (and mind you I'm a cartoonist who appreciates all types of art and animation).
On the other end of the spectrum the anime "frienRAB" I do have seem to not click with me as much as I used to with anime buddies in the past. One brainlessly "collects" (I'm using the safe word here, you guys know what anime fans do if they have a computer and a internet connection) whatever is new or shiny just to have it in some format but rarely actually watches stuff past the first few episodes. Another always talks to me about shows he's into except he comes off as being the snotty noob type that's all about yaoi, shorts series, subtitles, and illegal torrents. The last friend is basically a video game addict and puts Fullmetal Alchemist on a pedestal and has an interest in stuff like Haruhi and Slayers BUT unfortunately can't tear away from his precious XBox Live to care about anything else.
For me anime has also lost its uniqueness. The advent of Adult Swim and FOX getting a freakin' clue has expanded American animation into a more mature realm. Sure it's comedy, but it's still mature. Even so, I also appreciate the reserved innuendo of many of Dreamworks and Pixars films that seem to walk the line between being a family film and being something more than that.
I also like things like books written by Neil Gaiman, anything Kevin Smith or Joss Whedon work on. Sometimes I like to go to a theater and watch movies that have good word of mouth, just so I have something else to talk about.
I guess my point is: To some degree I always will be an anime fan but I feel that being involved with the fandom has changed so much over the course of the last few years that it does make my interests seem a little "dirty" and I myself would rather extend my interests to other forms of media from America and around the world than feel like I'm living in a boxed in otaku universe.
O-chan