I have a 2000 Chrysler 300M with a cylinder 6 misfire. I've replaced the spark plug in cylinder 6 (which I'm assuming from my manual) is the rearmost, driver-side plug as you look at it from the front. I've also swapped the ignition coil from the cylinder with one from another cylinder and when the code returned it was still on cylinder 6 only. I'm thinking it's probably a fuel injector. How hard would it be to swap a fuel injector from cylinder six with one from another cylinder?