Cowboys of Moo Mesa

That's more or less the same story I have, though I did watch one episode. It was the one where they find a shrink gun, or something. I recall the spider guy and bat guy were the villains, but that's all I can really remember.
 
Wikipedia Has an interresting article about it. Of note:

Ryan Brown is indeed the creator. A long time employee of Mirage, and close friend of Peter and Kevin.

CBS owns the rights to the series, so any DVD release would be handled from them.

Tales of the TMNT #21 features a C.O.W.boys crossover. (Gotta Love the title: A Bull Wrinkle in Time)
 
I don't remember the game OR the show that it was based on. However, I recently played the arcade game for the first time (they have it at a local Davanni's). It's moderately fun.
 
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